Possible alternative medicines for autoimmune diseases such as rheumatoid arthritis, Crohn's disease, ankylosing spondylitis

The research paper "The Growth Factor Progranulin Binds to TNF Receptors", which was jointly organized by Professor Yu Xiuping of the Institute of Pathogenic Biology of Shandong University School of Medicine and Professor Liu Chuanju of the New York University School of Medicine as the first author on March 10 and Is Therapeutic Against Inflammatory Arthritis in Mice "was accepted by Science magazine. Because the research has important theoretical significance and application value, it was selected by the editorial department and published in advance in Science Express. This is the first time that a doctoral student of Shandong University has published a research paper in the journal Science.

The study found that the receptor for growth factor progranulin (PGRN) is the tumor necrosis factor receptor TNFR, which answers the key questions that PGRN has discovered for more than 20 years, and combines two important research areas of PGRN and TNFα. Research on inflammation and autoimmune diseases provides new ideas. On this basis, the engineered protein Atsttrin (antagonist of TNF / TNFR signaling via targeting to TNF receptors) designed with PGRN as a template has significant therapeutic efficacy in animal models of rheumatoid arthritis. Atsttrin is more selective for TNFR, has an anti-inflammatory mechanism that is different from existing TNF antagonists, shows great potential for drug development, and may become autoimmune for rheumatoid arthritis, Crohn's disease, ankylosing spondylitis Alternative medicine for sexual diseases.

Due to the potential clinical application value of the study, domestic and foreign media have reported and commented on the research results. "Science Daily" in the United States published a comment entitled "Engineered Protein Has Potential for New Anti-inflammatory Treatment", saying that researchers have constructed new protein molecules derived from PGRN that may be used to treat rheumatoid arthritis and other inflammatory diseases Provide the basis for new treatments for diseases; will provide chronic autoimmune diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis, plaque-like psoriasis and psoriatic arthritis Provide alternative medicine. China Life Science First Net-Biocom website published a news titled "Shandong University, New York University Science Article", which wrote: "From New York University School of Medicine, Shandong University School of Medicine, Yale University School of Medicine and other places Of researchers have developed a protein that can be used to treat rheumatoid arthritis, thereby providing a new therapeutic target for the treatment of this autoimmune disease. The research results are published in Science. This study proposes treatment A new therapeutic target for TNFα-related diseases. Although there is no data to show whether Atsttrin can also be effective in humans, this study proposes a new idea for the treatment of such diseases. "By Massachusetts Technology Review, the world ’s oldest and well-known scientific journal in the United States hosted by the Institute of Technology (MIT), published an article entitled “A New Approach to Treating Rheumatoid Arthritis”, which reported that the protein found in the study was "An engineered protein that inhibits molecules that cause inflammation", which not only reduces rheumatic joint inflammation The condition also has the potential to reverse the course of the disease. Even the most successful joint inflammation drugs are only effective for half of the patients, and these drugs may increase the risk of cancer, activate other autoimmune environments, and will cost patients more than $ 20,000 in treatment costs each year. The new synthetic protein published in Science last week showed stronger specificity and can greatly reduce the patient's treatment expenditure.

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