Experimental studies have shown that bioactive ceramic scaffolds have successfully guided the loss of bone regeneration in animals and can be "harmlessly decomposed".
New York University School of Medicine dentists and experts say that the new bone will gradually replace the stent, and the implanted stent will be naturally absorbed by the body of the test animal. The research team described the progress in a series of reports, the latest report was published in the Journal of Tissue Engineering and Regenerative Medicine on July 25.
Modeling the bone piece to be replaced, using a 3D robot to print the implant holder, 3D printing technology is to spray the gel ink material with a fine dot print head, and print it onto the platform, and then repeat the process until the 2D layer Stacked into 3D objects and finally heated to the final ceramic form. The technology has been in existence for more than a decade and has only recently been used in the medical field to print replacement ears, skin and heart valves.
Scientists say the new ceramic stent is closer to the true bone shape and composition than other flexible plastic stents. Although the flexibility of the plastic stent is an advantage, it does not have healing capabilities.
An important feature of ceramic devices is that they are made of beta tricalcium phosphate, which has a compound of the same composition as beta tricalcium phosphate in the bone, which ensures the absorbability of the stent.
One of the secrets of the NYU stent to promote rapid bone growth is the dipyridamole coating, a blood thinner that has been shown to increase bone growth by more than 50%. In addition, dipyridamole can also accumulate bone cells to stimulate the formation of blood vessels and bone marrow in the new bone. The researchers say that the bones growing on the scaffold are as flexible as the natural bones.
In the latest experiment, the researchers experimented with ceramic scaffolds to repair the surgically made small holes in the mouse skull, repairing the rabbit's limbs and squats up to 1.2 cm in length.
The scientists found that after 6 months of implantation, an average of 77% of each stent was absorbed by the mammalian body. They also found that the new bone grew into a lattice-like structure of the scaffold and the scaffold dissolved. CT scans showed that there was almost no trace of beta tricalcium phosphate at the implant site, and beta tricalcium phosphate was the 3D original print material for the stent.
Subsequent weight-bearing tests showed that the strength of the new bone was the same as the original intact bone. Researchers say their next study will test stents for large animals that are patenting. They said it will take several years to enter clinical trials.
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