Moore et al., a Brownian Women and Children Hospital, reported that a new serum biochemical marker, HE4, is helpful for early diagnosis of ovarian cancer. The combined detection of HE4 and CA125 is more accurate than either marker alone. Related papers were published online at Gynecol Oncol on December 3, 2007.
Although CA125 can be used in patients with attachment tumors to predict whether ovarian cancer occurs, many benign gynecological lesions may also have elevated levels. To this end, researchers hope to identify new biomarkers to increase the diagnostic sensitivity and specificity of CA125.
The investigators included a total of 259 patients with aneurysm. Of the 233 patients who met the analytical criteria, 67 had aggressive ovarian epithelial cancer and 166 had benign ovarian tumors. Preoperative determination of serum CA125, soluble mesothelioma-associated peptide (SMRP), HE4, CA72-4, activin A, osteopontin, epidermal growth factor receptor (EGFR) and HER2 levels, and their final pathology The results were compared. All markers and their combinations were analyzed using a logistic regression model and sensitivity and specificity were assessed using a cross-validation assay.
The results showed that there were significant differences in the levels of various markers (except HER2) between benign and ovarian cancer patients. For a single marker, HE4 is the most sensitive (72.9%) for diagnosing ovarian cancer with a specificity of 95%. In terms of combined markers, CA125 and HE4 combined detection had the highest sensitivity (76.4%) and specificity of 95%. On the basis of this, combined with other markers, the sensitivity increased extremely low. For stage I lesions, HE4 is the best single-use marker, but combined detection of CA125 or other markers does not increase sensitivity.
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