In the past few decades, searching for active lead compounds with novel structure and potential medicine value from natural resources has become a hot field of pharmaceutical research. Research on the isolation of promising biologically active microbial-derived metabolites has provided exciting evidence. In many countries, edible fungus has been promoted as a traditional source of natural active compounds, and has also been recognized as a promising therapeutic agent. In the research results of medicinal edible fungi, many new biologically active compounds have been reported.
Researcher Xu Jianchu, Center of Mountain System Ecology, Kunming Institute of Botany, Chinese Academy of Sciences, and Dr. Kevin D Hyde, Mae Fah Luang Fungal Research Center, Thailand, have collaborated The mushroom extracts found have been summarized and put forward the initial idea of ​​commercial edible mushroom products as dietary supplements, health products and some new patented products on the market.
The research results show that many new compounds extracted from medicinal mushrooms have antioxidant, anti-tumor, anti-diabetic and anti-microbial effects. The biological activities are due to the presence of low molecular weight metabolites, such as triterpenes, phenols, polyketides And high molecular weight polysaccharides, proteins and polysaccharide-protein complexes. Today, bioactive compounds of natural origin are considered to be the most stable and successful new drug resources. Most of these drugs are recommended as adjuvant therapy and drug models, which can help patients improve the comfort of life, prevent certain diseases or reduce the side effects of medical treatment of chronic diseases. Even some effective mycotoxins, such as alkaloids, are optimized for medicinal chemistry and used to produce drugs to treat some neurological diseases, such as migraines and mental decline in the elderly. In addition, although these products have great potential in clinical treatment, the current emergence of drug-resistant pathogens, drug-resistant cancer cells and the emergence of various side effects from the use of existing drugs have led to the exploration of new natural compounds And further research on the determined reaction mechanism of the compound is more urgent, and it is also facing the growing demand for lead compounds and better therapeutic agents.
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